Description
Histone H2B is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains a histone fold domain with a C-terminal α-helix that facilitates nucleosome interactions and chromatin compaction, as well as an unstructured N-terminal tail that extends outside of the nucleosome core, both of which are subject to various post-translational modifications (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation.{57056,58056,58057} Phosphorylation of histone H2B at serine 14 (H2BS14Ph) is associated with DNA damage and induces apoptotic chromatin condensation.{60047,60048} H2BS14Ph also correlates with class switch recombination and somatic hypermutation in germinal center B cells.{60049} Cayman’s H2BS14Ph Monoclonal Antibody can be used for ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.
Synonyms: H2B (Phospho-Ser14)|H2BpS14|H2BpSer14|Phospho-Histone H2B Serine 14|Phosphorylated Histone H2B Serine 14
Immunogen: Peptide corresponding to H2BS14Ph
Formulation: 100 µg of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: ELISA, ICC, multiplex-based assays, WB
Origin:
Stability: 365 days
Application|ELISA||Application|Immunocytochemistry||Application|Multiplex||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Phosphorylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Phosphorylation
