Description
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Dimethylation of histone H3 at lysine 9 (H3K9Me2) is associated with transcriptional repression, whereas acetylation of histone H3 at lysine 14 (H3K14Ac) is associated with transcriptional activation.{48220,42735} H3K9Me2/K14Ac levels are increased in mouse differentiated embryonic stem cells (ESCs) compared with undifferentiated ESCs.{58041} Altered H3K9Me2/K14Ac levels have been found in tumor biopsies from patients with HER2+, triple-negative, luminal A-like, or luminal B-like breast cancer.{58042} Cayman’s Histone H3K9Me2/K14Ac Monoclonal Antibody recognizes histone H3 only when modified by both dimethylation at K9 and acetylation at K14. This antibody can be used for multiplex-based assay and Western blot (WB) applications.
Synonyms:
Immunogen: Peptide corresponding to H3K9Me2/K14Ac
Formulation: 100 µg of Protein A affinity-purified monoclonal antibody
Isotype: IgG
Applications: Multiplex-based assays and WB
Origin:
Stability: 365 days
Application|Multiplex||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Acetylated||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation
