Description
GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.{46949,46950} They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1-6, β1-4, γ1-3, δ, ε, π, θ, and ρ1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α1β2γ2 subunit-containing GABAA receptors, the major isoform found in the brain.{46950,46951} The β subunit of GABAA receptors interfaces with an α subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the γ subunit. Phosphorylation of the β2 subunit by PKC inhibits binding of the β2 subunit with the clathrin adaptor protein AP2 and reduces GABAA receptor endocytosis.{55097} SNPs in GABRB2, which encodes the β2 subunit isoform, have been found in patients with schizophrenia.{55096} Cayman’s GABAA Receptor β2 Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes the GABAA receptor β2 subunit at approximately 55 kDa from mouse and rat samples.
Synonyms: GABAA Receptor Subunit β2|GABRB2|Gamma-aminobutyric Acid (GABA) A Receptor, β2|Gamma-aminobutyric Acid Receptor Subunit β2
Immunogen: Fusion protein from the cytoplasmic loop of the β2 subunit of the rat GABAA receptor
Formulation: 100 µl of affinity-purified rabbit polyclonal antibody
Isotype:
Applications: WB
Origin:
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis
