Description
Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).{22400,22401,24611,24607} The R284M mutation in STING is associated with constitutive activation of downstream signaling. It increases the propensity of STING to dimerize and associate with the kinase TBK1 (Item No. 22817), enhancing the ability of STING to activate IRF3 (Item No. 22811) and NF-κB (Item No. 10009818) and induce a type I IFN response.{41454} However, the R284M mutation occurs outside of the dimerization region between positions 153-177, so rather than a direct effect on dimerization, it is predicted to promote or inhibit binding of a cellular factor that stabilizes or impairs STING dimerization. Cayman’s STING M284 variant Polyclonal Antibody preferentially detects overexpressed STING (R284M) versus wild-type STING by Western blot.
Synonyms: Endoplasmic Reticulum Interferon Stimulator|ERIS|Mediator of IRF3 Activation|MITA|MPYS|Stimulator of Interferon Genes|TMEM173|Transmembrane Protein 173
Immunogen: Synthetic peptide from the internal region of human STING protein containing the M284 mutation
Formulation: 500 µl of peptide affinity-purified antibody
Isotype: IgG,
Applications: WB at 1:200
Origin:
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease
