Description
Glutaredoxin 1 (Grx1) is a thiol-disulfide oxidoreductase and member of the thioredoxin family encoded by GLRX1 with a role in the maintenance of cellular thiol redox homeostasis.{53968} It is ubiquitously expressed and localizes to the cytosol, nucleus, and mitochondrial intermembrane space. Grx1 is a dithiol Grx that contains two active site cysteine residues, which catalyze the deglutathionylation of protein disulfides and glutathionylated proteins to regulate redox signal transduction and repair oxidized proteins.{49701,53969,49702} Knockdown or overexpression of GLRX1 enhances or reduces, respectively, oxidative stress-induced apoptosis in HEK293T cells.{49703} Glrx1-/- mice have increased bronchoalveolar lavage fluid (BALF) macrophage infiltration and lung glutathionylated protein levels induced by cigarette smoke compared with wild-type mice.{49704} Grx1 levels are decreased in postmortem brain from patients with Parkinson’s disease.{49702} Cayman’s Glutaredoxin 1 (human) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes Grx1 from human samples.
Synonyms: Glrx1|Grx1|Thioltransferase 1|TTF1
Immunogen: Recombinant human Grx1
Formulation: 150 µg of affinity-purified polyclonal antibody
Isotype:
Applications: IHC and WB
Origin: Animal/Goat
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutaredoxin
