Description
Adenosine receptor A2A Monoclonal Antibody (A2AR) is a multi-pass membrane protein that is normally localized to the plasma membrane.{15465} This receptor is part of the G protein-coupled receptor family that binds adenosine and serves multiple functions. Antagonists of this receptor have been targeted for the treatment of Parkinson’s disease.{15466,5049} Early reports found this receptor is found primarily in the brain striatum, but is also found in immune cells and other tissues as well.{15466} A2AR is comprised of 412 amino acids with an expected molecular weight of 45 kDa.{16148,15465} However multiple glycosylation sites exist that may explain the retarded migration observed by western blotting (45-50 kDa).{15465} This antibody has been extensively characterized and the epitope has been mapped to the third intracellular loop of the receptor.{16545}
Synonyms: A2AR|ADORA2A
Immunogen: human full length A2AR; the antibody recognizes amino acids 213-220 (SQPLPGER) as determined by epitope mapping
Formulation: 500 µg affinity-purified IgG2a in 500 µl PBS, pH 7.2, containing 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide
Isotype:
Applications: WB
Origin: Animal/Mouse
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease
