Description
Phosphoenolpyruvate carboxykinase (PEPCK) is a hormonally regulated enzyme responsible for the first committed step in gluconeogenesis, catalyzing the conversion of oxaloacetate to phosphoenolpyruvate.{13231,13234} PEPCK mRNA is most abundant in the liver, kidney cortex, and white adipose tissue but is also found in brown fat, the mammary gland during lactation, and the small intestine.{13234} Both non-insulin-dependent diabetes mellitus and streptozotocin-induced diabetes result in elevated PEPCK activity, protein, and mRNA.{13231,13237} Two isozymes of PEPCK have been identified, cytosolic and mitochondrial.{13240} Cayman’s PEPCK polyclonal antibody was generated against murine cytosolic PEPCK and detects the protein at 63 kDa by western blotting in rat and murine samples.
Synonyms: Pck1|PEPCK-c|Phosphoenolpyruvate carboxykinase
Immunogen: Peptide from the N-terminal region of mouse PEPCK
Formulation: 500 µl of peptide affinity-purified antibody
Isotype:
Applications: WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Blocking Peptides||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes
