Immunogen: Purified native AChE electric eel protein • Clone Designation 52E • Host: Mouse • Species reactivity: (+) Eel • Isotype: IgG2B • Applications: ELISA and WB

AChE (eel) Monoclonal Antibody (Clone 5E2) – 500 µg

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Cayman
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Acetylcholinesterase (AChE) is a homotetrameric carboxylesterase that is composed of four 70 kDa subunits with each subunit containing a single active site.{42309} It is a product of alternative splicing and can be membrane bound via a glycosyl-phosphatidylinositol anchor in the membrane or a proline-rich membrane anchor (PRIMA) peptide linker for erythrocyte and synaptic AChE, respectively, or soluble in water, with each form demonstrating identical catalytic activity.{42310} AChE is primarily found in red blood cells as well as at neuromuscular junctions and in the brain at cholinergic synapses where it hydrolyzes acetylcholine to acetate and choline to terminate synaptic transmission.{42310,42311} It accelerates amyloid-β (Aβ) fibrillogenesis in vitro and overexpression of AChE accelerates Aβ plaque formation and disease progression in the Tg2576 transgenic mouse model of Alzheimer’s disease.{42312} AChE activity is also increased in islets of Langerhans in rats with diabetes induced by streptozotocin (Item No. 13104). Cayman’s AChE (eel) Monoclonal Antibody (clone 5E2) can be used for Western blot and ELISA applications. This antibody recognizes AChE at ~72 kDa from electric eel samples.  

 

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SKU: 23855 - 500 µg Category:

Description

Immunogen: Purified native AChE electric eel protein • Clone Designation 52E • Host: Mouse • Species reactivity: (+) Eel • Isotype: IgG2B • Applications: ELISA and WB

Synonyms: Acetylcholinesterase

Immunogen: Purified native AChE electric eel protein

Formulation: 500 µg of protein G-purified IgG

Isotype: IgG2b

Applications: ELISA and WB

Origin:

Stability: 365 days

Product Type|Antibodies|Monoclonal Antibodies||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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