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Toll-Like Receptor 4 Monoclonal Antibody (Clone HTA125) – 1 ea

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Cayman
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The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. Among this family of receptors TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling.{17497,17500} The TLR4 cDNA codes for a protein consisting of 799 amino acids with approximate molecular weight of 88 kDa.{17501}  

 

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SKU: 13589 - 1 ea Category:

Description

Antigen: Ba/F3 cell line expressing human TLR4 cell surface antigen • Isotype: IgG2aK • Host: mouse, clone HTA125 • Cross Reactivity: (+) human and canine TLR4 • Application(s): FC (cell surface and intracellular), ICC, IP, and neutralization • TLR4 is mediator of innate immunity that is essential for microbial recognition and serves as one of the main mediators of LPS signaling.

Synonyms: TLR4

Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen

Formulation: 100 µg of Protein G purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide

Isotype: IgG2aκ

Applications: FC (cell surface and intracellular), ICC, IP, and neutralization

Origin: Animal/Mouse

Stability: 365 days

Application|Flow Cytometry||Application|Immunocytochemistry||Application|Immunoprecipitation||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition

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