Antigen: mouse TLR12 amino acids 911-926 • Host: rabbit • Cross Reactivity: (+) mouse and rat TLR12 • Application(s): FC (intracellular) and WB • TLR12 displays a distinct pattern of expression in macrophages

Toll-Like Receptor 12 Polyclonal Antibody – 1 ea

Brand:
Cayman
Storage:

The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. TLR12 displays a distinct pattern of expression in macrophages, liver, kidney, and bladder epithelial cells. TLR12 does not respond to known TLR ligands.  

 

Available on backorder

Add to quotes
SKU: 13586 - 1 ea Category:

Description

Antigen: mouse TLR12 amino acids 911-926 • Host: rabbit • Cross Reactivity: (+) mouse and rat TLR12 • Application(s): FC (intracellular) and WB • TLR12 displays a distinct pattern of expression in macrophages, liver, kidney, and bladder epithelial cells. TLR12 does not respond to known TLR ligands.

Synonyms: TLR12

Immunogen: mouse TLR12 amino acids 911-926

Formulation: 100 µg of protein G-purified IgG in 200 µl PBS containing 0.2% gelatin adn 0.05% sodium azide

Isotype:

Applications: WB and FC (intracellular)

Origin: Animal/Rabbit

Stability: 365 days

Application|Flow Cytometry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition

Related products