15(S)-HETE is produced from arachidonic acid by the enzyme 15-LO. In humans it is formed primarily in the respiratory epithelium

15(S)-HETE ELISA Kit – 480 solid wells

Brand:
Cayman
Storage:
-20

15(S)-HETE is produced from arachidonic acid by the enzyme 15-lipoxygenase (15-LO). In humans it is formed primarily in the respiratory epithelium, leukocytes, and reticulocytes.{2363} 15(S)-HETE has been detected in high concentrations in nasal secretions and may contribute to allergic rhinitis.{373} 15(S)-HETE has anti-inflammatory properties, inhibiting carrageenan-induced arthritis and lowering leukotriene B4 (LTB4) concentrations in the synovial fluid of dogs.{1014} It may regulate T-lymphocytes by inhibiting 5- and 12-LOs.{682} It is also a vasoconstrictor, constricting cerebral and coronary arteries of dogs in vitro and cerebral arteries of pigs in vivo.{1015} 15(S)-HETE may also play a role in cancer, inhibiting apoptosis by carcinosarcoma cells.{3814} Our 15(S)-HETE ELISA is a competitive assay that permits the measurement of 15(S)-HETE within the range of 78-10,000 pg/ml, typically with a sensitivity (80% B/B0) of 185.4 pg/ml. This assay is very specific for 15(S)-HETE, showing very low crossreactivity to other HETEs.  

 

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Description

15(S)-HETE is produced from arachidonic acid by the enzyme 15-LO. In humans it is formed primarily in the respiratory epithelium, leukocytes, and reticulocytes. It may contribute to allergic rhinitis, has anti-inflammatory properties, and acts as a vasoconstrictor. Cayman’s 15(S)-HETE ELISA is a competitive assay that permits the measurement of 15(S)-HETE within the range of 78-10,000 pg/ml, typically with a sensitivity (80% B/B0) of 185.4 pg/ml. This assay is very specific for 15(S)-HETE, showing very low crossreactivity to other HETEs.

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Synonyms:  15(S)-HETE EIA Kit

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Origin: Animal/Mouse|Animal/Bovine|Animal/Eel|Animal/Rabbit

Application|ELISA||Product Type|Assay Kits|ELISA||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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