A terpene alkaloid; active against a variety of bacteria and C. albicans (MICs = 0.6-10 µg/ml); scavenges DPPH and ABTS radicals in cell-free assays; increases LC3-II and catalase levels and reduces ROS production in normal WI38 lung fibroblasts and H1299

Dihydrocapsaicin – 10 mg

Brand:
Cayman
CAS:
19408-84-5
Storage:
-20
UN-No:
Non-Hazardous - /

Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper.{10293} Capsaicin is found in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain pure dihydrocapsaicin.{10294} Dihydrocapsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.{57050,57051,57052} It is active against E. faecalis, B. subtilis, S. aureus, P. aeruginosa, K. pneumoniae, E. coli, and C. albicans (MICs = 0.6-10 µg/ml).{57050} Dihydrocapsaicin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays. It increases LC3-II, a marker of autophagy, and catalase levels and reduces reactive oxygen species (ROS) production in normal WI38 lung fibroblasts and H1299, but not A549 or H460, lung cancer cells when used at a concentration of 200 µM.{57051} Dihydrocapsaicin (0.5 mg/kg, i.p.) induces cortical and systemic hypothermia and reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{57052}  

 

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SKU: 92355 - 10 mg Category:

Description

A terpene alkaloid; active against a variety of bacteria and C. albicans (MICs = 0.6-10 µg/ml); scavenges DPPH and ABTS radicals in cell-free assays; increases LC3-II and catalase levels and reduces ROS production in normal WI38 lung fibroblasts and H1299, but not A549 or H460, lung cancer cells at 200 µM; induces cortical and systemic hypothermia and reduces infarct volume in a rat model of ischemia-reperfusion injury induced by MCAO at 0.5 mg/kg

Formal name: N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-nonanamide

Synonyms: 

Molecular weight: 307.4

CAS: 19408-84-5

Purity: ≥98%

Formulation: A crystalline solid

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