An amide of oleic acid and agonist of CB1 receptors (Ki = 8.13 µM); selective for CB1 over CB2 receptors

Oleamide – 100 mg

Brand:
Cayman
CAS:
301-02-0
Storage:
-20
UN-No:
Non-Hazardous - /

Oleamide is an amide of oleic acid (Item No. 90260) and an agonist of cannabinoid 1 (CB1) receptors (Ki = 8.13 µM in a radioligand binding assay).{11820} It is selective for CB1 over CB2 receptors, where it inhibits binding of the CB receptor full agonist CP 55,940 by only 42.5% in HEK-293T cells expressing human CB2 receptors when used at a concentration of 100 µM. Oleamide (10 µM) inhibits cAMP accumulation induced by forskolin (Item No. 11018) in N1E 115 mouse neuroblastoma cells, an effect that is reversed by the CB1 antagonist SR141716A. Oleamide was first identified in the cerebrospinal fluid of sleep-deprived cats, and it has also been detected in the cerebrospinal fluid of rats and humans.{1317} In rats, it induces physiological sleep when administered at doses ranging from 5 to 50 mg and increases food intake when administered into the nucleus accumbens shell, and in group-housed and socially isolated mice, it has anxiolytic-like effects.{1317,42212,42213} Oleamide also induces transactivation of PPARα, PPARβ, and PPARγ and inhibits activity of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) at concentrations in the low micromolar range.{32696}  

 

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Description

An amide of oleic acid and agonist of CB1 receptors (Ki = 8.13 µM); selective for CB1 over CB2 receptors, where it inhibits binding of the CB receptor full agonist CP55,940 by only 42.5% in HEK-293T cells expressing human CB2 receptors at 100 µM; inhibits forskolin-induced cAMP accumulation in N1E 115 mouse neuroblastoma cells; induces physiological sleep in rats at 5-50 mg; increases food intake in rats and anxiolytic-like effects in group-housed and socially isolated mice; induces transactivation of PPARα, PPARβ, and PPARγ; inhibits SERCA

Formal name: 9Z-octadecenamide

Synonyms:  cis-9-Octadecenamide

Molecular weight: 281.5

CAS: 301-02-0

Purity: ≥98%

Formulation: A crystalline solid

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