An analog of the endocannabinoid AEA found in brain tissue and in chocolate whose biosynthesis is reduced in the intestine of rats following food deprivation; an endogenous

Oleoyl Ethanolamide – 10 mg

Brand:
Cayman
CAS:
111-58-0
Storage:
-20
UN-No:
Non-Hazardous - /

Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate.{5291} It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue,{2874} but its biosynthesis is reduced in the intestine of rats following food deprivation.{9302} OEA is an endogenous, potent agonist for PPARα, exhibiting an EC50 value of 120 nM in a transactivation assay.{11423} Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice.{9302,11423} These data indicate that OEA regulates food intake by a PPARα-mediated mechanism.  

 

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Description

An analog of the endocannabinoid AEA found in brain tissue and in chocolate whose biosynthesis is reduced in the intestine of rats following food deprivation; an endogenous, potent agonist for PPARα (EC50 = 120 nM in a transactivation assay); systemic administration suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild type mice, but not in PPARα knockout mice

Formal name: N-(2-hydroxyethyl)-9Z-octadecenamide

Synonyms:  OEA|Oleic Acid Ethanolamide

Molecular weight: 325.5

CAS: 111-58-0

Purity: ≥98%

Formulation: A crystalline solid

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