A nucleotide and dual P2Y2 and P2Y4 receptor agonist (EC50s = 55 and 80 nM

Uridine 5′-triphosphate (sodium salt) – 5 g

Brand:
Cayman
CAS:
19817-92-6
Storage:
-20
UN-No:
Non-Hazardous - /

Uridine 5′-triphosphate (UTP) is a nucleotide and dual agonist of purinergic P2Y2 and P2Y4 receptors (EC50s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors).{53844,53845} It is selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = >10,000 nM).{53845} UTP stimulates proliferation of PANC-1 cells (EC50 = 13.1 μM), an effect that can be prevented by siRNA against the P2Y2 receptor.{53844} It induces vasoconstriction in perfused isolated canine epicardial coronary artery in a concentration-dependent manner.{53846} UTP is formed from uridine monophosphate (UMP) by two sequential phosphorylations and can be converted to cytidine 5′-triphosphate (CTP; Item No. 18147).{53847} It also reacts with glucose-1-phosphate (Item No. 30566) to form UDP-glucose (Item No. 15602), a precursor in the biosynthesis of glycogen.{52573}  

 

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SKU: 9003530 - 5 g Category:

Description

A nucleotide and dual P2Y2 and P2Y4 receptor agonist (EC50s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors); selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = >10,000 nM); stimulates proliferation of PANC-1 cells (EC50 = 13.1 μM), an effect that can be prevented by siRNA against the P2Y2 receptor; induces vasoconstriction in perfused isolated canine epicardial coronary artery; formed from UMP and can be converted to CTP; reacts with glucose-1-phosphate to form UDP-glucose

Formal name: uridine 5′-(tetrahydrogen triphosphate), trisodium salt

Synonyms:  NSC 20260|UTP

Molecular weight: 550.1

CAS: 19817-92-6

Purity: ≥95%

Formulation: A crystalline solid

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