An isoprenoid with anticancer activity; induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes from 1-20 µM; induces apoptosis in Huh7 cells via loss of the mitochondrial membrane potential and activation of ICE and CPP32 at 10 µM; inhibits LSD1 (IC50 = 46.97 µM)

Geranylgeranoic Acid – 500 µg

Brand:
Cayman
CAS:
83807-40-3
Storage:
-80
UN-No:
Non-Hazardous - /

Geranylgeranoic acid (GGA) is an isoprenoid that has been found in S. chinensis and has anticancer activity.{53890} It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 µM. GGA (10 µM) induces apoptosis in Huh7 cells via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).{53891} It also inhibits lysine-specific demethylase 1 (LSD1; IC50 = 46.97 µM).{53892}  

 

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SKU: 9003474 - 500 µg Category:

Description

An isoprenoid with anticancer activity; induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes from 1-20 µM; induces apoptosis in Huh7 cells via loss of the mitochondrial membrane potential and activation of ICE and CPP32 at 10 µM; inhibits LSD1 (IC50 = 46.97 µM)

Formal name: 3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenoic acid

Synonyms:  GGA

Molecular weight: 304.5

CAS: 83807-40-3

Purity: ≥95%

Formulation: A solution in methyl acetate

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