A prodrug form of gemcitabine; enters cells through passive diffusion; inhibits the growth of L1210

NUC-1031 – 5 mg

Brand:
Cayman
CAS:
840506-29-8
Storage:
-20
UN-No:
Non-Hazardous - /

NUC-1031 is a prodrug form of the anticancer nucleoside analog gemcitabine (Item No. 11690).{43518,43517} NUC-1031 is more lipophilic than gemcitabine and enters cells through passive diffusion.{43518} It inhibits the growth of L1210, CEM, MP-2, and BxPC-3 cancer cells in vitro (IC50 = 35, 30, 60, and 40 nM, respectively).{43517} NUC-1031 (0.076 mmol/kg) reduces tumor growth in Mia-PaCa-2 and BxPC-3 mouse xenograft models, which are partially responsive and resistant to gemcitabine, respectively.{43519}  

 

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SKU: 9003247 - 5 mg Category:

Description

A prodrug form of gemcitabine; enters cells through passive diffusion; inhibits the growth of L1210, CEM, MP-2, and BxPC-3 cancer cells in vitro (IC50s = 35, 30, 60, and 40 nM, respectively); reduces tumor growth in Mia-PaCa-2 and BxPC-3 mouse xenograft models at 0.076 mmol/kg

Formal name: N-(2′-deoxy-2′,2′-difluoro-P-phenyl-5′-cytidylyl)-L-alanine, phenylmethyl ester

Synonyms: 

Molecular weight: 580.5

CAS: 840506-29-8

Purity: ≥98% (mixture of diastereomers)

Formulation: A crystalline solid

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