A carnitine derivative; increases the basal release of PGE2 and 6-keto prostaglandin F1α in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils; increases the basal release of thromboxane B2 in non-neutrophil-contaminated carrageenan-stimulated isolated rat peritoneal cells; reduces the production of ROS and decreases NOX2

Propionyl-L-carnitine (chloride) – 25 mg

Brand:
Cayman
CAS:
119793-66-7
Storage:
-20
UN-No:
Non-Hazardous - /

Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.{24843} Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto-prostaglandin F1α (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells.{24843} It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.{47116} Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.{47117}  

 

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Description

A carnitine derivative; increases the basal release of PGE2 and 6-keto prostaglandin F1α in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils; increases the basal release of thromboxane B2 in non-neutrophil-contaminated carrageenan-stimulated isolated rat peritoneal cells; reduces the production of ROS and decreases NOX2, NOX4, and ICAM-1 expression in HUVECs; increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia at 10 mg per animal

Formal name: 3-carboxy-N,N,N-trimethyl-2R-(1-oxopropoxy)-1-propanaminium, monochloride

Synonyms:  C3 Carnitine|Levocarnitine propionate|L-Propionylcarnitine|ST 261

Molecular weight: 253.7

CAS: 119793-66-7

Purity: ≥98%

Formulation: A crystalline solid

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