A hybrid molecule patterned after N-arachidonoyl serotonin; while saturated 11- or 12-carbon fatty acids linked to serotonin potently inhibit capsaicin-induced TRPV1 channel activation (IC50 = 0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM)

Palmitoyl Serotonin – 10 mg

Brand:
Cayman
CAS:
212707-51-2
Storage:
-20
UN-No:
Non-Hazardous - /

Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin (Catalog No. 70665). Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain.{18121,18122} The effects of replacing the arachidonoyl portion with the saturated 16-carbon palmitoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50 = 0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).{18121}  

 

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Description

A hybrid molecule patterned after N-arachidonoyl serotonin; while saturated 11- or 12-carbon fatty acids linked to serotonin potently inhibit capsaicin-induced TRPV1 channel activation (IC50 = 0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM), the effects of palmitoyl serotonin are unknown

Formal name: N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-hexadecanamide

Synonyms: 

Molecular weight: 414.6

CAS: 212707-51-2

Purity: ≥98%

Formulation: A neat solid

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