An atypical antipsychotic; binds to D2

Lurasidone – 10 mg

Brand:
Cayman
CAS:
367514-87-2
Storage:
-20
UN-No:
Non-Hazardous - /

Lurasidone is an atypical antipsychotic that binds to dopamine D2, serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT1A, and 5-HT7, and α2C-adrenergic receptors (Kis = 1.68, 2.03, 6.75, 0.495, and 10.8 nM, respectively).{42146} In vivo, pre-training administration of lurasidone (1 and 3 mg/kg) reverses impairment in step-through latency and passive avoidance in a foot shock test induced by MK-801 (Item No. 10009019) in rats. It reverses MK-801-induced learning impairment in the Morris water maze as well as reference and working memory impairment in the radial arm maze in rats.{42147} Lurasidone also decreases immobility in the tail suspension and forced swim tests, indicating antidepressant-like activity in mice.{42148} Formulations containing lurasidone have been used in the treatment of schizophrenia and mood disorders.  

 

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Description

An atypical antipsychotic; binds to D2, 5-HT2A, 5-HT1A, and 5-HT7, and α2C-ARs (Kis = 1.68, 2.03, 6.75, 0.495, and 10.8 nM, respectively); reverses MK-801-induced impairment in step-through latency and passive avoidance in a foot shock test in rats at 1 and 3 mg/kg; reverses MK-801-induced learning impairment in the Morris water maze as well as reference and working memory impairment in the radial arm maze in rats; decreases immobility in the tail suspension and forced swim tests in mice

Formal name: (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione

Synonyms: 

Molecular weight: 492.7

CAS: 367514-87-2

Purity: ≥98%

Formulation: A crystalline solid

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