A CB2 receptor inverse agonist with Ki values ranging from 0.3 to 5.6 nM; selective for CB2 over CB1 receptors

SR 144528 – 25 mg

Brand:
Cayman
CAS:
192703-06-3
Storage:
-20
UN-No:
Non-Hazardous - /

SR 144528 is a cannabinoid (CB) receptor 2 inverse agonist with Ki values ranging from 0.3 to 5.6 nM.{7912} It is selective for CB2 over CB1 receptors, where it has Ki values ranging from 305 to >10,000 nM. SR 144528 blocks the inhibitory effects of CP 55,940 on forskolin-induced adenylyl cyclase activity in CHO cells expressing hCB2 (IC50 = 10 nM) but not in cells expressing hCB1 (IC50 = >10 µM).{17199} SR 144528 has been used to investigate the contribution of the CB2 receptor in the control of pain initiation as well as suppression of inflammation and immune activation.{7921,16339,14732,16336}  

 

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SKU: 9000491 - 25 mg Category:

Description

A CB2 receptor inverse agonist with Ki values ranging from 0.3 to 5.6 nM; selective for CB2 over CB1 receptors, where it has Ki values ranging from 305 to >10,000 nM; blocks the inhibitory effects of CP 55,940 on forskolin-induced adenylyl cyclase activity in CHO cells expressing hCB2 (IC50 = 10 nM) but not in cells expressing hCB1 (IC50 = >10 µM)

Formal name: 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide

Synonyms:  ,, ,,,,SR144528,

Molecular weight: 476.1

CAS: 192703-06-3

Purity: ≥98%

Formulation: A crystalline solid

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