A bacterial-derived pentapeptide that irreversibly inhibits aspartic proteases

Pepstatin A – 5 mg

Brand:
Cayman
CAS:
26305-03-3
Storage:
-20
UN-No:
Non-Hazardous - /

Pepstatin A is a bacterial-derived chemotactic pentapeptide that irreversibly inhibits aspartic proteases, including pepsin, gastricsin, renin, cathepsin E, and cathepsin D.{23717} Pepstatin A has been reported to stimulate human neutrophil degranulation (EC50 = 0.75 μM) and super oxide production (EC50 = 1.5 μM).{23718} Pepstatin A has been widely used as a research tool in studies of protease mechanisms and biological functions and has been examined as a therapeutic agent for inflammatory conditions including gastric ulcer, edema, and hypertension.{23716}  

 

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Description

A bacterial-derived pentapeptide that irreversibly inhibits aspartic proteases, including pepsin, gastricsin, renin, cathepsin E, and cathepsin D; examined as a therapeutic agent for inflammatory conditions including gastric ulcer, edema, and hypertension

Formal name: N-(3-methyl-1-oxobutyl)-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]-L-alaninamide

Synonyms:  NSC 272671|Pepsin Inhibitor S 735A

Molecular weight: 685.9

CAS: 26305-03-3

Purity: ≥98%

Formulation: A crystalline solid

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