A long-chain saturated fatty acid; binds to the DNA binding domain of p53 (Kd = 12 nM) and inhibits the DNA binding activity; inhibits rat DNA polymerase β and human DNA polymerase λ activity at 100 µM; inhibits human DNA topoisomerase I and II relaxation activity at 25 µM; liver levels are reduced in rats fed a high-fat or a high-fat high-cholesterol diet

Docosanoic Acid – 5 g

Brand:
Cayman
CAS:
112-85-6
Storage:
-20
UN-No:
Non-Hazardous - /

Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.  

 

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SKU: 9000338 - 5 g Category:

Description

A long-chain saturated fatty acid; binds to the DNA binding domain of p53 (Kd = 12 nM) and inhibits the DNA binding activity; inhibits rat DNA polymerase β and human DNA polymerase λ activity at 100 µM; inhibits human DNA topoisomerase I and II relaxation activity at 25 µM; liver levels are reduced in rats fed a high-fat or a high-fat high-cholesterol diet

Formal name:

Synonyms:  Behenic Acid|C22:0|DCA|NSC 32364

Molecular weight: 340.6

CAS: 112-85-6

Purity: ≥98%

Formulation: A crystalline solid

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