An enantiomer of the short-lived oral anti-coagulant acenocoumarol with a longer plasma elimination half-life (6.6 hours) and slower plasma clearance (1.9 L/hour)

(R)-Acenocoumarol – 1 mg

Brand:
Cayman
CAS:
66556-77-2
Storage:
-20
UN-No:
Non-Hazardous - /

Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro. Acenocoumarol has a single chiral center that gives rise to two different enantiomeric forms. (R)-Acenocoumarol has a longer plasma elimination half-life (6.6 hours) and slower plasma clearance (1.9 L/hour), compared to the (S)-enantiomer (1.8 hours, 28.5 L/hour).{15996} The R-enantiomer is rapidly absorbed from the gastrointestinal tract with essentially complete oral bioavailability, whereas (S)-acenocoumarol undergoes extensive first-pass metabolism.{15996} Perhaps related to these pharmacokinetic characteristics, (R)-acenocoumarol is more potent in vivo as an anti-coagulant than the (S)-enantiomer. As the clearance of acenocoumarol is ~20-fold faster than that for warfarin, the plasma concentrations of acenocoumarol are substantially lower than those for warfarin in patients receiving long-term treatment.  

 

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SKU: 9000337 - 1 mg Category:

Description

An enantiomer of the short-lived oral anti-coagulant acenocoumarol with a longer plasma elimination half-life (6.6 hours) and slower plasma clearance (1.9 L/hour), compared to the (S)-enantiomer (1.8 hours, 28.5 L/hour); rapidly absorbed from the gastrointestinal tract with essentially complete oral bioavailability; more potent in vivo than the (S)-enantiomer

Formal name: 4-hydroxy-3-[(1R)-1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one

Synonyms:  (R)-Acenocoumarin|(R)-Nicoumalone

Molecular weight: 353.3

CAS: 66556-77-2

Purity: ≥98%

Formulation: A crystalline solid

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