A phenol with diverse biological activities; decreases NO production in mouse peritoneal exudate macrophages from 6-25 µM; scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays; inhibits 5-LO (IC50 = 0.1 µM for the recombinant human enzyme) and the synthesis of leukotrienes in human PMNs (IC50 = 7 µM); reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis at 200 mg/kg

Carnosol – 10 mg

Brand:
Cayman
CAS:
5957-80-2
Storage:
-20
UN-No:
Non-Hazardous - /

Carnosol is a phenol that has been found in rosemary (R. officinalis) and has diverse biological activities.{8781,6842,53877,6784} It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 µM.{8781} Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays.{6842} It inhibits 5-lipoxygenase (5-LO; IC50 = 0.1 µM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC50 = 7 µM).{53877} In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis.{6784}  

 

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SKU: 89800 - 10 mg Category:

Description

A phenol with diverse biological activities; decreases NO production in mouse peritoneal exudate macrophages from 6-25 µM; scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays; inhibits 5-LO (IC50 = 0.1 µM for the recombinant human enzyme) and the synthesis of leukotrienes in human PMNs (IC50 = 7 µM); reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis at 200 mg/kg

Formal name: 1,3,4,9,10,10aS-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2H-9S,4aR-(epoxymethano)phenanthren-12-one

Synonyms:  NSC 39143

Molecular weight: 330.4

CAS: 5957-80-2

Purity: ≥98%

Formulation: A crystalline solid

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