An inhibitor of CETP; inhibits plasma CETP with an IC50 value of 9 µM; in rabbits given an atherogenic diet

Dalcetrapib – 5 mg

Brand:
Cayman
CAS:
211513-37-0
Storage:
-20
UN-No:
Non-Hazardous - /

Cholesteryl ester transfer protein (CETP) is an exchange protein which transfers cholesteryl esters from HDL to VLDL, IDL, and LDL in exchange for triglycerides.{11793,15303} Dalcetrapib is an inhibitor of CETP that exhibits an IC50 value of 9 µM for plasma CETP in rabbits.{8320} Inhibition of CETP by dalcetrapib in rabbits given an atherogenic diet leads to elevation of HDL, decreased VLDL, and attenuation of the induced atherosclerosis.{8320} In human subjects, dalcetrapib also inhibits CETP activity and increases plasma HDL levels but it does not reduce the risk of recurrent cardiovascular events.{15303,21933}  

 

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SKU: 89450 - 5 mg Category:

Description

An inhibitor of CETP; inhibits plasma CETP with an IC50 value of 9 µM; in rabbits given an atherogenic diet, increases HDL, decreases VLDL, and attenuates induced atherosclerosis; in humans, inhibits CETP activity and increases HDL levels but does not reduce the risk of recurrent cardiovascular events

Formal name: S-[2-[[[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino]phenyl]propanethioic acid, 2-methyl ester

Synonyms:  JTT-705

Molecular weight: 389.6

CAS: 211513-37-0

Purity: ≥98%

Formulation: A crystalline solid

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