YC-1 is an NO-independent activator of soluble guanylyl cyclase. It inhibits collagen (10 µg/ml) and thrombin (0.1 U/ml) induced platelet aggregation with IC50 values of 11.7-14.6 and 57.3-59.3 µM

YC-1 – 5 mg

Brand:
Cayman
CAS:
170632-47-0
Storage:
-20
UN-No:
Non-Hazardous - /

YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase. It inhibits collagen (10 µg/ml) and thrombin (0.1 U/ml) induced platelet aggregation with IC50 values of 11.7-14.6 and 57.3-59.3 µM, respectively.{4218,4219} In the absence of NO or carbon monoxide (CO), 200 µM YC-1 increases the activity of purified soluble guanylyl cyclase 12-fold, with an ED50 value of 20 µM.{4220} At a concentration of 200 µM, YC-1 potentiates the maximal activity of soluble guanylyl cyclase in the presence of NO or CO by 40% and >3,000%, respectively.  

 

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SKU: 81560 - 5 mg Category:

Description

YC-1 is an NO-independent activator of soluble guanylyl cyclase. It inhibits collagen (10 µg/ml) and thrombin (0.1 U/ml) induced platelet aggregation with IC50 values of 11.7-14.6 and 57.3-59.3 µM, respectively.{4218,4219} In the absence of NO or CO, 200 µM YC-1 increases the activity of purified soluble guanylyl cyclase 12-fold, with an ED50 value of 20 µM.{4220} At a concentration of 200 µM, YC-1 potentiates the maximal activity of soluble guanylyl cyclase in the presence of NO or CO by 40% and >3,000%, respectively.

Formal name: 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol

Synonyms: 

Molecular weight: 304.3

CAS: 170632-47-0

Purity: ≥99%

Formulation: A crystalline solid

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