1400W is a potent

1400W (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
214358-33-5
Storage:
-20
UN-No:
Non-Hazardous - /

1400W is a potent, selective inhibitor of iNOS.{4277} Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively.{4277} In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS.{4277} In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.{5066}  

 

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Description

1400W is a potent, selective inhibitor of iNOS.{4277} Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively.{4277} In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS.{4277} In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.{5066}

Formal name: N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride

Synonyms: 

Molecular weight: 250.2

CAS: 214358-33-5

Purity: ≥98%

Formulation: A crystalline solid

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