The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists

GW 9662 – 1 mg

Brand:
Cayman
CAS:
22978-25-2
Storage:
-20
UN-No:
Non-Hazardous - /

The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo.{7575,8224} Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class.{8241} There are many PPARγ agonists, including 15-deoxy-Δ12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived.{8461,8930} However, only a few antagonists have been reported.{8953} GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM.{8953} It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.{9318}  

 

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Description

The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists, including 15-deoxy-.DELTA.12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM. It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.

Formal name: 2-chloro-5-nitrobenzanilide

Synonyms: 

Molecular weight: 276.7

CAS: 22978-25-2

Purity: ≥98%

Formulation: A crystalline solid

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