A CB2 receptor inverse agonist (Ki = 435 nM for recombinant human CB2); selective for CB2 over CB1 receptors (Ki = >20 µM); reduces basal production of inositol phosphate and increases forskolin-induced accumulation of cAMP in HEK293 cells expressing human CB2 receptors from 0.001-1 µM; inhibits LPS-induced NO and PGE2 production in J774 macrophages

IMMA – 5 mg

Brand:
Cayman
CAS:
2854-32-2
Storage:
-20
UN-No:
Non-Hazardous - /

IMMA is a cannabinoid (CB) receptor 2 inverse agonist (Ki = 435 nM for recombinant human CB2).{4996,11066} It is selective for CB2 over CB1 receptors (Ki = >20 µM). IMMA (0.001-1 µM) reduces basal production of inositol phosphate and increases forskolin-induced accumulation of cAMP in HEK293 cells expressing human CB2 receptors.{11066} It inhibits LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2: Item No. 14010) production in J774 macrophages in a concentration-dependent manner.{57143}  

 

Available on backorder

Add to quotes
SKU: 70275 - 5 mg Category:

Description

A CB2 receptor inverse agonist (Ki = 435 nM for recombinant human CB2); selective for CB2 over CB1 receptors (Ki = >20 µM); reduces basal production of inositol phosphate and increases forskolin-induced accumulation of cAMP in HEK293 cells expressing human CB2 receptors from 0.001-1 µM; inhibits LPS-induced NO and PGE2 production in J774 macrophages

Formal name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-ethanone

Synonyms:  BML-190|Indomethacin Morpholinylamide|LM-4131

Molecular weight: 426.9

CAS: 2854-32-2

Purity: ≥98%

Formulation: A crystalline solid

Related products

  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 50 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 50 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 10 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 10 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 100 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 50 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 50 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page