A CB2 receptor inverse agonist (Ki = 435 nM for recombinant human CB2); selective for CB2 over CB1 receptors (Ki = >20 µM); reduces basal production of inositol phosphate and increases forskolin-induced accumulation of cAMP in HEK293 cells expressing human CB2 receptors from 0.001-1 µM; inhibits LPS-induced NO and PGE2 production in J774 macrophages

IMMA – 100 mg

Brand:
Cayman
CAS:
2854-32-2
Storage:
-20
UN-No:
Non-Hazardous - /

IMMA is a cannabinoid (CB) receptor 2 inverse agonist (Ki = 435 nM for recombinant human CB2).{4996,11066} It is selective for CB2 over CB1 receptors (Ki = >20 µM). IMMA (0.001-1 µM) reduces basal production of inositol phosphate and increases forskolin-induced accumulation of cAMP in HEK293 cells expressing human CB2 receptors.{11066} It inhibits LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2: Item No. 14010) production in J774 macrophages in a concentration-dependent manner.{57143}  

 

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SKU: 70275 - 100 mg Category:

Description

A CB2 receptor inverse agonist (Ki = 435 nM for recombinant human CB2); selective for CB2 over CB1 receptors (Ki = >20 µM); reduces basal production of inositol phosphate and increases forskolin-induced accumulation of cAMP in HEK293 cells expressing human CB2 receptors from 0.001-1 µM; inhibits LPS-induced NO and PGE2 production in J774 macrophages

Formal name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-ethanone

Synonyms:  BML-190|Indomethacin Morpholinylamide|LM-4131

Molecular weight: 426.9

CAS: 2854-32-2

Purity: ≥98%

Formulation: A crystalline solid

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