Description
O-ASHA is an irreversible, non-selective inhibitor of COX-1 and COX-2. Aspirin is the best-studied example of an irreversible COX inhibitor, acting via the acetylation of the active site serine residue 529 in human COX-1. O-ASHA inhibits ovine COX-1 in a time-dependent, irreversible manner with a 50% B/B0 value of approximately 4.5 mM.{9607}
Formal name: N-(acetyloxy)-2-hydroxy benzamide
Synonyms: AcSHA|O-ASHA
Molecular weight: 195.2
CAS: 199854-00-7
Purity: ≥98%
Formulation: A crystalline solid
