A non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2

(±)-Flurbiprofen – 1 g

Brand:
Cayman
CAS:
5104-49-4
Storage:
22
UN-No:
De Minimis - 2811 / 6.1

(±)-Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively).{1286} In vivo, (±)-flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.{39761} (±)-Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.{39762} Formulations containing (±)-flurbiprofen have been used to manage pain and inflammation associated with arthritis.  

 

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SKU: 70250 - 1 g Category:

Description

A non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively); reduces carrageenan-induced hind paw edema and yeast-induced fever in rats from 0.3-4.8 mg/kg; reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis; reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model at 5 mg/kg,

Formal name: (±)-2-fluoro-α-methyl-[1,1′-biphenyl]-4-acetic acid

Synonyms:  Ansaid

Molecular weight: 244.3

CAS: 5104-49-4

Purity: ≥99%

Formulation: A crystalline solid

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