Description
A selective inhibitor of 15-hydroxy PGDH (IC50 = ~10 µM)
Formal name: 5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid
Synonyms: CK47A
Molecular weight: 328.3
CAS: 78028-01-0
Purity: ≥98%
Formulation: A crystalline solid
CAY10397 – 5 mg
Brand:
Cayman
CAS:
78028-01-0
Storage:
-20
UN-No:
Non-Hazardous - /
Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). This enzyme oxidizes the 15-hydroxyl group and hydrogenates the 13,14-double bond, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity. CAY10397 is a selective inhibitor of 15-hydroxy PGDH with an IC50 of approximately 10 µM.{8455} CAY10397 acts to prolong the lifetime and activity of endogenously produced prostaglandins both in cell culture and in vivo.
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