A natural sesquiterpene lactone which inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml); induces apoptosis in cancer cells

Parthenolide – 50 mg

Brand:
Cayman
CAS:
20554-84-1
Storage:
-20
UN-No:
Non-Hazardous - /

Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml).{20976} Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription.{20973,20975} This compound has also been shown to block inflammation by inhibiting signaling through NF-κB.{20974} Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.{20972}  

 

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SKU: 70080 - 50 mg Category:

Description

A natural sesquiterpene lactone which inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml); induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription; directly binds the pattern recognition receptor NOD2

Formal name: 2,3,6,7,7aS,8,10aS,10bR-octahydro-1aR,5-dimethyl-8-methylene-(4E)-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one

Synonyms: 

Molecular weight: 248.3

CAS: 20554-84-1

Purity: ≥98%

Formulation: A crystalline solid

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