C8 Ceramide (d18:1/8:0) is a cell-permeable analog of naturally occurring ceramides. Unlike C2 ceramide

C8 Ceramide (d18:1.8:0) – 10 mg

Brand:
Cayman
CAS:
74713-59-0
Storage:
-20
UN-No:
Non-Hazardous - /

C8 Ceramide (d18:1/8:0) is a cell-permeable analog of naturally occurring ceramides. Unlike C2 ceramide, it is metabolized within cells to generate natural ceramides, often causing a dramatic increase in cellular ceramide levels.{5258} For this reason, treatment of cells with C8 ceramide (d18:1/8:0) may more closely mimic the effects of ceramide elevation than does treatment with shorter chain ceramide analogs. C8 Ceramide (d18:1/8:0) likely mediates many diverse biological activities, as do natural ceramides. It promotes the differentiation of human keratinocytes{5185} and induces apoptosis of both human leukemia cells and the U937 cell line.{5258,4667}  

 

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SKU: 62540 - 10 mg Category:

Description

C8 Ceramide (d18:1/8:0) is a cell-permeable analog of naturally occurring ceramides. Unlike C2 ceramide, it is metabolized within cells to generate natural ceramides, often causing a dramatic increase in cellular ceramide levels. For this reason, treatment of cells with C8 ceramide (d18:1/8:0) may more closely mimic the effects of ceramide elevation than does treatment with shorter chain ceramide analogs. C8 Ceramide (d18:1/8:0) likely mediates many diverse biological activities, as do natural ceramides. It promotes the differentiation of human keratinocytes and induces apoptosis of both human leukemia cells and the U937 cell line.

Formal name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide

Synonyms:  C8 Ceramide|Cer(d18:1/8:0)|Ceramide (d18:1/8:0)|N-Octanoylsphingosine|N-octanoyl-D-erythro-Sphingosine

Molecular weight: 425.7

CAS: 74713-59-0

Purity: ≥98%

Formulation: A crystalline solid

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