C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities

C2 Ceramide (d18:1/2:0) – 1 mg

Brand:
Cayman
CAS:
3102-57-6
Storage:
-20
UN-No:
Non-Hazardous - /

C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells,{2751} induction of apoptosis,{884} activation of protein phosphatase 2A,{2757} and inhibition of the mitochondrial respiratory chain.{5031} C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts{2759} and stimulates the growth of bovine aortic smooth muscle cells.{3512} The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.{6012}  

 

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Description

C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells,{2751} induction of apoptosis,{884} activation of protein phosphatase 2A,{2757} and inhibition of the mitochondrial respiratory chain.{5031} C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts{2759} and stimulates the growth of bovine aortic smooth muscle cells.{3512} The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.{6012}

Formal name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-acetamide

Synonyms:  C2 Ceramide|Cer(18:1/2:0)|Ceramide (d18:1/2:0)|N-acetoyl-D-erythro-sphingosine

Molecular weight: 341.5

CAS: 3102-57-6

Purity: ≥98%

Formulation: A crystalline solid

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