An endogenous CB receptor ligand that is 10-100 times less potent than 2-AG in ligand binding affinity and agonist activity at the CB1 receptor; 2-AG undergoes rapid isomerization to 1-AG

1-Arachidonoyl Glycerol – 5 mg

Brand:
Cayman
CAS:
35474-99-8
Storage:
-80
UN-No:
De Minimis - 1648 / 3

The glyceryl esters of arachidonic acid have been proposed as endogenous cannabinoid ligands.{4614} 2-AG is 10 to 100 times more potent than 1-AG in ligand binding affinity and agonist activity at the CB1 receptor, and is thus considered to be the natural ligand.{5306} However, 2-AG is chemically unstable and undergoes rapid isomerization to 1-AG (synonymous with 1(3)-AG) both in vitro and in vivo. 1-AG is a frequent contaminant in synthetic 2-AG preparations, and can markedly reduce their cannabinergic potency. 1-AG is a weak CB1 receptor agonist and may have other pharmacologic properties.  

 

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SKU: 62150 - 5 mg Category:

Description

An endogenous CB receptor ligand that is 10-100 times less potent than 2-AG in ligand binding affinity and agonist activity at the CB1 receptor; 2-AG undergoes rapid isomerization to 1-AG, which makes it a frequent contaminant in synthetic 2-AG preparations, markedly reducing their cannabinergic potency

Formal name: 5Z,8Z,11Z,14Z-eicosatetraenoic acid, 1-glyceryl ester

Synonyms:  1-AG

Molecular weight: 378.6

CAS: 35474-99-8

Purity: ≥95% (as a 9:1 mixture of the 1-AG and 2-AG)

Formulation: A solution in acetonitrile

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