Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ.{8499} One of these substances was recently isolated and purified from oxLDL

Azelaoyl PAF – 1 mg

Brand:
Cayman
CAS:
354583-69-0
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ.{8499} One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF.{8953} Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-Δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.{8953}  

 

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SKU: 60924 - 1 mg Category:

Description

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ.{8499} One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF.{8953} Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-.DELTA.12,14-PGJ2, and equipotent with rosiglitazone as a ligand for this receptor.{8953}

Formal name: 1-O-hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine

Synonyms: 

Molecular weight: 651.9

CAS: 354583-69-0

Purity: ≥98%

Formulation: A solution in ethanol

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