A lactone form of (±)5(6)-DiHET; induces vasodilation of isolated canine coronary arterioles

(±)5(6)-DiHET lactone – 100 µg

Brand:
Cayman
CAS:
213126-92-2
Storage:
-20
UN-No:
De Minimis - 1170 / 3

5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.{39654} 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively.{12606} It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME (Item No. 80210).{43011}  

 

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Description

A lactone form of (±)5(6)-DiHET; induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively; induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner

Formal name: tetrahydro-6-[(3Z,6Z,9Z)-1-hydroxy-3,6,9-pentadecatrien-1-yl]-2H-pyran-2-one

Synonyms:  (±)5,6-DiHETrE lactone

Molecular weight: 320.5

CAS: 213126-92-2

Purity: ≥98%

Formulation: A solution in ethanol

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