(±)11-HDHA is an autoxidation product of DHA in vitro.{7479

(±)11-HDHA – 50 µg

Brand:
Cayman
CAS:
87018-59-5
Storage:
-20
UN-No:
De Minimis - 1170 / 3

(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.{7479,7491} It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.{7480,7490,7492} DHA is metabolized to 11(S)-HDHA by human platelets and canine retina.{7483,7486,7484,7492} In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets.{7483,7484,7492} 11(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 µM, respectively.{7484,7481} (±)11-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.  

 

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Description

(±)11-HDHA is an autoxidation product of DHA in vitro.{7479,7491} It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.{7480,7490,7492} DHA is metabolized to 11(S)-HDHA by human platelets and canine retina.{7483,7486,7484,7492} In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets.{7483,7484,7492} 11(S)-HDHA is an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 µM, respectively.{7484,7481} (±)11-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.

Formal name: (±)11-hydroxy-4Z,7Z,9E,13Z,16Z,19Z-docosahexaenoic acid

Synonyms:  11-hydroxy Docosahexaenoic Acid

Molecular weight: 344.5

CAS: 87018-59-5

Purity: ≥98%

Formulation: A solution in ethanol

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