An inhibitor of ABCG2; selectively inhibits JC-1 efflux in Ig-MXP3 cells overexpressing ABCG2 over Jurkat cells overexpressing ABCB1 (IC50s = 0.13 and 4.65 µM

ML-230 – 10 mg

Brand:
Cayman
CAS:
1776055-05-0
Storage:
-20
UN-No:
Non-Hazardous - /

ML-230 is an inhibitor of ATP-binding cassette family G member 2 (ABCG2).{61128} It selectively inhibits JC-1 efflux in Ig-MXP3 cells overexpressing ABCG2 over Jurkat cells overexpressing ABCB1 (IC50s = 0.13 and 4.65 µM, respectively). ML-230 enhances inhibition of IGROV-1/T8 ovarian cancer cell colony formation induced by topotecan (Item No. 14129).{61129} Intratumoral injection of ML-230 (100 nM) and topotecan reduces tumor size in an IGROV-1/T8 mouse xenograft model.  

 

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SKU: 32552 - 10 mg Category:

Description

An inhibitor of ABCG2; selectively inhibits JC-1 efflux in Ig-MXP3 cells overexpressing ABCG2 over Jurkat cells overexpressing ABCB1 (IC50s = 0.13 and 4.65 µM, respectively); intratumoral injection with topotecan, reduces tumor size in an IGROV-1/T8 mouse xenograft model at 100 nM

Formal name: 3-furanyl[4-[5-(2-furanyl)-2-phenylpyrazolo[1,5-a]pyrimidin-7-yl]-1-piperazinyl]-methanone

Synonyms:  CID44640177

Molecular weight: 439.5

CAS: 1776055-05-0

Purity: ≥98%

Formulation: A crystalline solid

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