12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S)

12(S)-HEPE – 100 µg

Brand:
Cayman
CAS:
116180-17-7
Storage:
-20
UN-No:
De Minimis - 1170 / 3

12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway.{6402} The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.  

 

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SKU: 32550 - 100 µg Category:

Description

12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway.{6402} The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.

Formal name: 12S-hydroxy-5Z,8Z,10E,14Z,17Z-eicosapentaenoic acid

Synonyms: 

Molecular weight: 318.5

CAS: 116180-17-7

Purity: ≥98%

Formulation: A solution in ethanol

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