A derivative of sorafenib; selectively inhibits proliferation of BEL-7402

CAY10773 – 10 mg

Brand:
Cayman
CAS:
1648546-79-5
Storage:
-20
UN-No:
- /

CAY10773 is a derivative of the ferroptosis inducer sorafenib (Item No. 10009644).{54492} It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 µM, respectively) over non-cancerous HCV-29 cells (IC50 = 23.19 µM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 µM but induces ferroptosis at concentrations greater than or equal to 6 µM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 µM) also induces autophagy with incubation times longer than eight hours.  

 

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SKU: 31806 - 10 mg Category:

Description

A derivative of sorafenib; selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 µM, respectively) over non-cancerous HCV-29 cells (IC50 = 23.19 µM); induces apoptosis in T24 cells at 2-6 µM; induces ferroptosis in T24 cells at ≥6 µM when incubated for ≥10 hours; induces autophagy at ≥6 µM when incubated for >8 hours

Formal name: N-(3,4-dichlorophenyl)-N′-[3-[(4-quinazolinylamino)methyl]phenyl]-urea

Synonyms: 

Molecular weight: 438.3

CAS: 1648546-79-5

Purity: ≥98%

Formulation: A crystalline solid

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