A σ receptor ligand (Kis = 61 and 42 nM for σ1 and σ2 receptors

1,3-Di-o-tolylguanidine – 250 g

Brand:
Cayman
CAS:
97-39-2
Storage:
-20
UN-No:
Limited Quantity - 2811 / 6.1

1,3-Di-o-tolylguanidine (DTG) is a sigma (σ) receptor ligand (Kis = 61 and 42 nM for σ1 and σ2 receptors, respectively).{54533} In vivo, DTG (10, 15, and 20 mg/kg, i.p.) increases latency to tail withdrawal in the tail flick test and induces hypothermia in mice.{54534} It decreases infarct size and increases the number of cortical and hippocampal NeuN-positive neurons in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{54535}  

 

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SKU: 31736 - 250 g Category:

Description

A σ receptor ligand (Kis = 61 and 42 nM for σ1 and σ2 receptors, respectively); increases latency to tail withdrawal in the tail flick test and induces hypothermia in mice at 10, 15, and 20 mg/kg; decreases infarct size and increases the number of cortical and hippocampal NeuN-positive neurons in a rat model of MCAO-induced ischemia-reperfusion injury

Formal name: N,N′-bis(2-methylphenyl)-guanidine

Synonyms:  DTG|NSC 132023|NSC 473

Molecular weight: 239.3

CAS: 97-39-2

Purity: ≥95%

Formulation: A crystalline solid

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