A derivative of gemcitabine; in nanoparticle form it has synergistic effects when used in combination with cisplatin nanoparticles in vitro at a one-to-one molar ratio (IC50s = 5.95 and 34.8 for the nanoparticle combination and gemcitabine monophosphate alone

Gemcitabine monophosphate – 500 µg

Brand:
Cayman
CAS:
116371-67-6
Storage:
-20
UN-No:
Non-Hazardous - /

Gemcitabine monophosphate is a monophosphate form of the deoxycytidine analog gemcitabine (Item No. 9003096).{40694} It has synergistic effects when used in nanoparticle form in combination with cisplatin nanoparticles in vitro at a one-to-one molar ratio (IC50s = 5.95 and 34.8 for the nanoparticle combination and gemcitabine monophosphate alone, respectively). In a stroma-rich mouse xenograft model, the nanoparticle combination of gemcitabine and cisplatin inhibits tumor growth and increases apoptosis.  

 

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Description

A derivative of gemcitabine; in nanoparticle form it has synergistic effects when used in combination with cisplatin nanoparticles in vitro at a one-to-one molar ratio (IC50s = 5.95 and 34.8 for the nanoparticle combination and gemcitabine monophosphate alone, respectively); in nanoparticle form it inhibits tumor growth and increases apoptosis in a stroma-rich mouse xenograft model

Formal name: 2′-deoxy-2′,2′-difluoro-5′-cytidylic acid

Synonyms: 

Molecular weight: 343.2

CAS: 116371-67-6

Purity: ≥95%

Formulation: A crystalline solid

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