A sodium channel blocker and local anesthetic; levorotary stereoisomer of bupivacaine; inhibits INa by 57.8% in isolated guinea pig ventricular myocytes at 10 μM; reduces the Vmax and action potential duration to 76.7 and 83.4% of controls

Levobupivacaine (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
27262-48-2
Storage:
-20
UN-No:
Non-Hazardous - /

Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine (Item No. 16618).{58122,58123,42580} It inhibits cardiac sodium channel currents (INa) by 57.8% in isolated guinea pig ventricular myocytes when used at a concentration of 10 μM.{58122} Levobupivacaine (10 μM) reduces the maximal rate of depolarization (Vmax) and action potential duration to 76.7 and 83.4% of controls, respectively, in isolated guinea pig papillary muscle.{58123} It induces a complete block of proprioception, motor function, and nociception in the hindleg of rats when administered at a dose of 7.7 mM by percutaneous injection into the sciatic nerve.{42580}  

 

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SKU: 31596 - 500 mg Category:

Description

A sodium channel blocker and local anesthetic; levorotary stereoisomer of bupivacaine; inhibits INa by 57.8% in isolated guinea pig ventricular myocytes at 10 μM; reduces the Vmax and action potential duration to 76.7 and 83.4% of controls, respectively, in isolated guinea pig papillary muscle at 10 μM; induces a complete block of proprioception, motor function, and nociception in the hindleg of rats at 7.7 mM by percutaneous injection into the sciatic nerve

Formal name: 1-butyl-N-(2,6-dimethylphenyl)-(2S)-2-piperidinecarboxamide, monohydrochloride

Synonyms:  (S)-(–)-Bupivacaine

Molecular weight: 324.9

CAS: 27262-48-2

Purity: ≥98%

Formulation: A crystalline solid

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