A NOX4 inhibitor (IC50 = 5 µM); selective for NOX4 over NOX2 (IC50 = 40 µM); reduces glucose-induced production of ROS and cytotoxicity in isolated human pancreatic islets at 10 µM; decreases blood glucose levels in an intravenous glucose tolerance test in mice fed a high-fat diet at an estimated 3.8 mg/kg per day

GLX-351322 – 10 mg

Brand:
Cayman
CAS:
835598-94-2
Storage:
-20
UN-No:
Non-Hazardous - /

GLX-351322 is an inhibitor of NADPH oxidase 4 (NOX4; IC50 = 5 µM).{61052} It is selective for NOX4 over NOX2 (IC50 = 40 µM). GLX-351322 (10 µM) reduces glucose-induced production of reactive oxygen species (ROS) and cytotoxicity in isolated human pancreatic islets. It decreases blood glucose levels in an intravenous glucose tolerance test in mice fed a high-fat diet when administered in the drinking water at an estimated dose of 3.8 mg/kg per day.  

 

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SKU: 31523 - 10 mg Category:

Description

A NOX4 inhibitor (IC50 = 5 µM); selective for NOX4 over NOX2 (IC50 = 40 µM); reduces glucose-induced production of ROS and cytotoxicity in isolated human pancreatic islets at 10 µM; decreases blood glucose levels in an intravenous glucose tolerance test in mice fed a high-fat diet at an estimated 3.8 mg/kg per day

Formal name: 2-[[2-[4-(2-furanylcarbonyl)-1-piperazinyl]acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid, ethyl ester

Synonyms: 

Molecular weight: 431.5

CAS: 835598-94-2

Purity: ≥98%

Formulation: A crystalline solid

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