A sesquiterpene with diverse biological activities; inhibits lipid peroxidation in rat hepatic microsomes (IC50 = 9.8 μM); scavenges hydroxyl and DPPH radicals in cell-free assays; inhibits LPS-induced nitric oxide production in RAW 264.7 cells (EC50 = 10.1 μM); cytotoxic to RAW 264.7 cells (CC50s = 29.8 and 30.8 μM in the presence and absence

Guaiazulene – 10 g

Brand:
Cayman
CAS:
489-84-9
Storage:
-20
UN-No:
Non-Hazardous - /

Guaiazulene is a sesquiterpene that has been found in M. chamomilla and has diverse biological activities.{59011,59012,59013} It inhibits lipid peroxidation in rat hepatic microsomes (IC50 = 9.8 μM), as well as scavenges hydroxyl and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell-free assays.{59011} It inhibits LPS-induced nitric oxide production in RAW 264.7 cells (EC50 = 10.1 μM) but is cytotoxic to RAW 264.7 cells at higher concentrations with cytotoxic concentration (CC50) values of 29.8 and 30.8 μM in the presence and absence, respectively, of LPS.{59012} Guaiazulene is cytotoxic to N2a neuroblastoma cells and primary rat neurons in a concentration-dependent manner.{59013} It inhibits decreases in hepatic glutathione (GSH) levels induced by paracetamol (acetaminophen; Item No. 10024) in rats when administered at a dose of 250 mg/kg.{59011}  

 

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SKU: 31506 - 10 g Category:

Description

A sesquiterpene with diverse biological activities; inhibits lipid peroxidation in rat hepatic microsomes (IC50 = 9.8 μM); scavenges hydroxyl and DPPH radicals in cell-free assays; inhibits LPS-induced nitric oxide production in RAW 264.7 cells (EC50 = 10.1 μM); cytotoxic to RAW 264.7 cells (CC50s = 29.8 and 30.8 μM in the presence and absence, respectively, of LPS); cytotoxic to N2a neuroblastoma cells and primary rat neurons; inhibits paracetamol-induced decreases in hepatic GSH in rats at 250 mg/kg

Formal name: 1,4-dimethyl-7-(1-methylethyl)-azulene

Synonyms:  NSC 4714

Molecular weight: 198.3

CAS: 489-84-9

Purity: ≥95%

Formulation: A solid

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