An inhibitor of G6PDH; reduces NADPH levels in a variety of cultured cells

G6PDi-1 – 5 mg

Brand:
Cayman
CAS:
2457232-14-1
Storage:
-20
UN-No:
Non-Hazardous - /

G6PDi-1 is a reversible and noncompetitive inhibitor of glucose-6-phosphate dehydrogenase (G6PDH; IC50 = 0.07 µM), the enzyme that converts G6P to 6-phosphogluconolactone using NADP+ as a cofactor in the first step of the pentose phosphate pathway.{55375} G6PDi-1 (10 and 50 µM) reduces NADPH levels in a variety of cultured cells, including red blood cells and T cells. It decreases colony formation of HCT116 cells when used at concentrations of 20 and 30 µM, an effect that can be rescued by the antioxidant N-acetyl cysteine. G6PDi-1 decreases the production of cytokines induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and ionomycin (Item No. 10004974) in T cells and prevents PMA-induced oxidative burst in neutrophils.  

 

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SKU: 31484 - 5 mg Category:

Description

An inhibitor of G6PDH; reduces NADPH levels in a variety of cultured cells, including red blood cells and T cells, at 10 and 50 µM; decreases colony formation of HCT116 cells at 20 and 30 µM; decreases PMA- and ionomycin-induced cytokine production in T cells

Formal name: 4-((5-oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile

Synonyms:  Glucose-6-phosphate Dehydrogenase Inhibitor 1

Molecular weight: 284.3

CAS: 2457232-14-1

Purity: ≥98%

Formulation: A crystalline solid

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